Toll-Like Receptors Promote Mitochondrial Translocation of Nuclear Transcription Factor Nuclear Factor of Activated T-Cells in Prolonged Microglial Activation
نویسندگان
چکیده
منابع مشابه
Microglial phenotype is regulated by activity of the transcription factor, NFAT (nuclear factor of activated T cells).
The transcription factor family, nuclear factor of activated T cells (NFAT), regulates immune cell phenotype. Four different calcium/calmodulin-regulated isoforms have been identified in the periphery, but isoform expression in microglia, the resident immune cells of the CNS, has not been fully defined. In this study microglial NFAT isoform expression and involvement in regulating inflammatory ...
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ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2015
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.2455-14.2015